Test provides high sensitivity and ease of use with a simple, water-based collection method designed to be more patient-friendly. The patented brush sampling replaces unpleasant fecal collection or smearing. No dietary or medicinal restrictions, enhanced specificity and sensitivity for more productive colonoscopies. The InSure^® ONE™ is based on the immunochemical detection of human hemoglobin (Hb) as an indicator of blood in the stool. The assay uses a monoclonal antibody to capture Hb on a test strip during test development. Since globin does not survive passage through the upper gastrointestinal (GI) tract, the presence of globin in the stool indicates bleeding in the colon or rectum. Clinical studies have demonstrated high sensitivity and specificity of the InSure^® ONE™ test in colorectal cancer screening.