The new Tissue-Tek^® Cryo3^® Plus is a precision instrument used to freeze and section tissue specimens. A temperature-controlled blade holder keeps the blade cold during sectioning. The Tissue-Tek Cryo3 Plus D and DM models use ozone technology to disinfect and substantially reduce the level of pathogens inside the cryochamber. Ozone gas spreads evenly inside the chamber and contacts areas that most other disinfection methods cannot reach. On-demand ozone disinfection protects users from pathogens in between mandated CAP manual decontaminations. The DM model is equipped with a motorized microtome to intermittently or continuously section specimens as selected by the operator. In addition, a unique anti-roll rake produces smooth, quality sections and simplifies specimen transfer to slides.