For sterilization with autoclaves and ethylene oxide (EtO) chambers. Dual-process (internal and external) steam indicators: will change color when proper sterilization has been met. Leak-resistant. Provides reliable confirmation of sterilization. Maintains sterilization for up to 12 months once sterile, and items remain sealed in the pouch. Made with medical-grade paper and an easy-to-open thumb notch. When used properly, pouch helps to comply with CDC infection control guidelines.